Well, given that she’s not in their lives now, and there is some canon that they’re a ship, I would say yes. Louis still would have stayed with Lestat, he was the only vampire Louis knew. Although he did threaten to leave Lestat before Claudia appeared, I doubt he would have followed through with that.

Are childless couples any less committed to each other because they never had a child? Or couples who have lost a child, does that destroy the relationship they had that existed before the child was there? I don’t think so. 

Kids can heal a relationship, or strain it, it’s all in the chemistry of the parents and kids involved. Claudia did bind Louis to Lestat for a time, and then she drove a wedge between them. Maybe if she hadn’t been brought into their lives, they might have been better off ;A; She got rather pointy near the end… 

… Aaaaand that’s what fanworks are for!